反应详情

Analogously to Example 11, from 0.48 g. 5,6-diamino-3,3-dimethylindolin-2-one and 0.36 g. oenanthic acid, after heating with 4.5 g. polyphosphoric acid for 30 minutes at a bath temperature of 200° C., there is obtained 0.7 g. of crude product which is dissolved in 35 ml. ethanol, treated with active charcoal, filtered and the clear filtrate evaporated in a vacuum. The evaporation residue, after trituration with diethyl ether, gives 0.37 g. of the title compound in the form of the monohydrate; m.p. 233°-234° C.

1. customthere is obtained 0.7 g
2. dissolutionof crude product which is dissolved in 35 ml
3. filtrationfiltered
4. customthe clear filtrate evaporated in a vacuum
5. customThe evaporation residue, after trituration with diethyl ether, gives 0.37 g