Piperazine → HCID 10668222, compound

HRID 568822Notes

Reaction equation

HRID 568822 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:23])[C:7]([C:20]([OH:22])=[O:21])=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=2)=[CH:4][C:3]=1[F:24].[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[C:18]([C:15]1[CH:14]=[CH:13][C:12]([N:9]2[C:10]3[C:5](=[CH:4][C:3]([F:24])=[C:2]([N:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)[CH:11]=3)[C:6](=[O:23])[C:7]([C:20]([OH:22])=[O:21])=[CH:8]2)=[CH:17][CH:16]=1)#[N:19]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19783732HCID 19783732, compound

Product 1

HCID 10668222HCID 10668222, compound

Procedure

In the described fashion as Example 1(e), the above acid (7) (R6 =C2H5, R=p-cyanophenyl), after reacting with piperazine, can give the desired 1-p-cyanophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid (9) ##STR30## R=p-cyanophenyl) and its hydrochloride salt.

Sources & evidence

ORD record
ord-023f56774bd24982b0cf62174155d1b1
Source dataset
uspto-grants-1988_03
Patent number
US04730000

Reaction notes

Loading…