Trifluoroacetic acid → HCID 117622903, compound

HRID 56892Notes

Reaction equation

HRID 56892 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:33]#[N:34])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][C:25]3([CH3:31])[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)[C:17]([O:19]C(C)(C)C)=[O:18])[C:10](=[O:32])[CH:9]=2)[CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:33]#[N:34])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][C:25]3([CH3:31])[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)[C:17]([OH:19])=[O:18])[C:10](=[O:32])[CH:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622789HCID 117622789, compound

Product 1

HCID 117622903HCID 117622903, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

210 mg (431 μmol) of tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-(4-methyltetrahydro-2H-pyran-4-yl)propanoate (racemate) in 4.3 ml of dichloromethane and 598 μl (7.76 mmol) of TFA were reacted according to General Method 6A. Yield: 210 mg (purity 83%, 94% of theory)

Sources & evidence

ORD record
ord-09df70220c1c40d9bdd0b35f215b80f9
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

Loading…