Lithium Hydroxide → 2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-methylbutanoic acid

HRID 56902Notes

Reaction equation

HRID 56902 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:26]#[N:27])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH:22]([CH3:24])[CH3:23])[C:17]([O:19]CC)=[O:18])[C:10](=[O:25])[CH:9]=2)[CH:7]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:26]#[N:27])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH:22]([CH3:23])[CH3:24])[C:17]([OH:19])=[O:18])[C:10](=[O:25])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 117622794HCID 117622794, compound

Product 1

HCID 1176225402-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-methylbutanoic acid

Procedure

3.70 g (9.52 mmol) of ethyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-methylbutanoate (racemate) were hydrolysed with lithium hydroxide according to General Method 6B. Yield: 2.80 g (82% of theory)

Sources & evidence

ORD record
ord-a36aeade83f74d7dbaa800c393ffd661
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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