反应详情

480 mg of β-carboline-3-carboxylic acid estyl ester are dissolved in 40 ml of tetrahydrofuran and added drop by drop to a Grignard solution consisting of 144 mg of magnesium chips and 660 mg of ethylbromide in 10 ml of diethyl ether. After 2 hours of reflux it is mixed with aqueous ammonium chloride solution and extracted with methylene chloride. After drying, filtering and evaporation, the residue is chromatographed on silica gel with toluene/glacial acetic acid/water=10:10:1 as eluant. 120 mg of 3-(1-ethyl-1-hydroxy-propyl)-β-carboline are obtained as oil.

1. additionadded drop by drop to a Grignard solution
2. temperatureAfter 2 hours of reflux it
3. extractionextracted with methylene chloride
4. customAfter drying
5. filtrationfiltering
6. customevaporation
7. customthe residue is chromatographed on silica gel with toluene/glacial acetic acid/water=10:10:1 as eluant