Dimethylamine → HCID 20148413, compound

HRID 569026Notes

Reaction equation

HRID 569026 reaction equation
C(O[C:4]([C:6]1[CH:7]=[C:8]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]1[CH:13]=[N:12][CH:11]=[CH:10][C:9]2=1)=[O:5])C.[CH3:19][NH:20][CH3:21]>C=C>[CH3:19][N:20]([CH3:21])[C:4]([C:6]1[CH:7]=[C:8]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]1[CH:13]=[N:12][CH:11]=[CH:10][C:9]2=1)=[O:5]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 13315115HCID 13315115, compound

Product 1

HCID 20148413HCID 20148413, compound

Reagents, catalysts & solvents 1

HCID 6325EthyleneSolvent

Procedure

150 mg of 6-ethoxycarbonyl-β-carboline are heated in 5 ml of ethylene gylcol with 2 ml of dimethylamine solution for 20 hours to 100° C. After cooling, it is placed on ice, extracted with ethyl acetate and the organic phase is dried, filtered and concentrated. 50 mg of 6-dimethylaminocarbonyl-β-carboline are obtained as oil after chromatography on silica gel with methylene chloride/ethanol=10:1.

Workup

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. customthe organic phase is dried
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-add9c74c1d444bdd96b0b82f2af42f84
Source dataset
uspto-grants-1988_03
Patent number
US04731358

Reaction notes

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