Allyl bromide → HCID 53979939, compound

HRID 569042Notes

Reaction equation

HRID 569042 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([NH2:19])[CH:16]=3)[NH:11][C:10]=2[CH:9]=[N:8][CH:7]=1)=[O:5])[CH3:2].N1(C2CCCCCCCCCC2)CCCCCC[CH2:24][CH2:23][CH2:22]N1.[CH2:42](Br)[CH:43]=[CH2:44]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([N:19]([CH2:44][CH:43]=[CH2:42])[CH2:24][CH:23]=[CH2:22])[CH:16]=3)[NH:11][C:10]=2[CH:9]=[N:8][CH:7]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 13315139HCID 13315139, compoundHCID 57346892Diazabicycloundecane

Product 1

HCID 53979939HCID 53979939, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.28 g of 6-amino-β-carboline-4-carboxylic acid ethyl ester, 0.18 g of diazabicycloundecane and 0.26 g of allylbromide in 5 ml of ethanol is heated for 3 hours to 70° C. Then the solution is evaporated. The evaporation residue is extracted with ethyl acetate and water, the combined extracts are evaporated and chromatographed on silica gel with methylene chloride/methanol=5:1. Yield: 0.05 g.

Workup

  1. customThen the solution is evaporated
  2. extractionThe evaporation residue is extracted with ethyl acetate and water
  3. customthe combined extracts are evaporated
  4. customchromatographed on silica gel with methylene chloride/methanol=5:1

Sources & evidence

ORD record
ord-725422a58abb4fc2a0e8a033cd31051b
Source dataset
uspto-grants-1988_03
Patent number
US04731358

Reaction notes

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