反应详情

温度

60 °C

An initial suspension of N,N-dimethyl-N'-(7-acetoxythieno[2,3-c]pyridine-2-sulfonyl)formamidine (2.0 g, 6.1 mmol) in 10 N sodium hydroxide (4 ml) diluted with water (15 ml) was warmed at 60° C. for 1 hour. This clear solution was cooled and acidified with concentrated hydrochloric acid to give a precipitate of product. This precipitate (1.2 g) was collected by filtration and dried in a vacuum oven. Recrystallization by dissolution in a minimum amount of hot dimethyl sulfoxide, followed by dilution with ethanol gave 0.76 g (54% yield) of pure product; m.p. 295°-297° C.

1. temperatureThis clear solution was cooled
2. customto give a precipitate of product
3. filtrationThis precipitate (1.2 g) was collected by filtration
4. customdried in a vacuum oven
5. customRecrystallization
6. dissolutionby dissolution in a minimum amount of hot dimethyl sulfoxide