2-Sulfamoylthieno[3,2-c]pyridine → 2-Sulfamoylthieno[3,2-c]pyridine-5-oxide

HRID 569057Notes

Reaction equation

HRID 569057 reaction equation
S(C1SC2=C[N+]([O-])=CC=C2C=1)(=O)(=[O:3])N.[S:15]([C:19]1[S:27][C:26]2[CH:25]=[CH:24][N:23]=[CH:22][C:21]=2[CH:20]=1)(=[O:18])(=[O:17])[NH2:16].S(C1SC2=CN=CC=C2C=1)(=O)(=O)N>>[S:15]([C:19]1[S:27][C:26]2[CH:25]=[CH:24][N+:23]([O-:3])=[CH:22][C:21]=2[CH:20]=1)(=[O:17])(=[O:18])[NH2:16]

Participants

4

Reactant 3

HCID 201485682-Sulfamoylthieno[3,2-c]pyridineHCID 20148577Thieno[2,3-c]pyridine-2-sulfonamideHCID 201485922-Sulfamoylthieno[2,3-c]pyridine-6-oxide

Product 1

HCID 201485882-Sulfamoylthieno[3,2-c]pyridine-5-oxide

Procedure

The title compound was prepared according to the procedure described for 2-sulfamoylthieno[2,3-c]pyridine-6-oxide (Example 3) except 2-sulfamoylthieno[3,2-c]pyridine was substituted for 2-sulfamoylthieno[2,3-c]pyridine. The title compound was obtained in 69% yield; m.p. 252°-254° C., after recrystallization from dimethyl sulfoxide/ethanol.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-873c4810246b4ba380915ff87431ab50
Source dataset
uspto-grants-1988_03
Patent number
US04731368

Reaction notes

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