Trifluoroacetic acid → HCID 117622418, compound

HRID 56910Notes

Reaction equation

HRID 56910 reaction equation
[Cl:1][C:2]1[C:3]([C:21]2[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:4][C:5](=[O:20])[N:6]([CH:8]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:9]([O:11]C(C)(C)C)=[O:10])[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[C:3]([C:21]2[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:4][C:5](=[O:20])[N:6]([CH:8]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:9]([OH:11])=[O:10])[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622804tert-Butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-4-methylpentanoate

Product 1

HCID 117622418HCID 117622418, compound

Procedure

139 mg (purity 85%, 0.27 mmol) of tert-butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-4-methylpentanoate (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 87 mg (84% of theory)

Sources & evidence

ORD record
ord-e904aa120be84616a2892da6d75764e1
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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