Trifluoroacetic acid → HCID 117622890, compound

HRID 56913Notes

Reaction equation

HRID 56913 reaction equation
[Cl:1][C:2]1[C:3]([C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=2[C:31]#[N:32])=[CH:4][C:5](=[O:23])[N:6]([CH:8]([CH2:16][CH2:17][O:18][C:19]([F:22])([F:21])[F:20])[C:9]([O:11]C(C)(C)C)=[O:10])[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[C:3]([C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=2[C:31]#[N:32])=[CH:4][C:5](=[O:23])[N:6]([CH:8]([CH2:16][CH2:17][O:18][C:19]([F:20])([F:21])[F:22])[C:9]([OH:11])=[O:10])[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622909tert-Butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-4-(trifluoromethoxy)butanoate

Product 1

HCID 117622890HCID 117622890, compound

Procedure

244 mg (purity 92%, 0.46 mmol) of tert-butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-4-(trifluoromethoxy)butanoate (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 237 mg (purity 84%, quant.)

Sources & evidence

ORD record
ord-0d1f5e6990284d7cb39dd4189c3927b9
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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