Trifluoroacetic acid → HCID 18612296, compound

HRID 569131Notes

Reaction equation

HRID 569131 reaction equation
[CH3:1][NH:2][C:3]([O:5][C@@H:6]([CH2:27][O:28]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:4].FC(F)(F)C(O)=O>ClCCl>[CH3:1][NH:2][C:3]([O:5][C@@H:6]([CH2:27][OH:28])[CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18612294HCID 18612294, compound

Product 1

HCID 18612296HCID 18612296, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.57 g of (R)-2-O-(methyl-carbamoyl)-1-O-octadecyl-3-O-tritylglycerine in 15 ml of dichloromethane is treated with 0.5 ml of trifluoroacetic acid. The solution is washed with water and with sodium bicarbonate, dried and evaporated. The residue is recrystallized from dichloromethane-n-hexane. There is obtained (S)-2-O-(methylcarbamoyl)-1-O-octadecylglycerine of melting point 68°-69° C.

Workup

  1. washThe solution is washed with water and with sodium bicarbonate
  2. customdried
  3. customevaporated
  4. customThe residue is recrystallized from dichloromethane-n-hexane

Sources & evidence

ORD record
ord-04b8a2bc343542a99845c7c6ad3c93b0
Source dataset
uspto-grants-1988_03
Patent number
US04731373

Reaction notes

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