1H-1,2,4-Triazole → HCID 13259981, compound

HRID 569196Notes

Reaction equation

HRID 569196 reaction equation
Cl[CH2:2][C:3](=[O:18])[C:4]([CH3:17])([CH3:16])[CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=1[Cl:15].C(=O)([O-])[O-].[K+].[K+].[NH:25]1[CH:29]=[N:28][CH:27]=[N:26]1>CC(C)=O>[Cl:15][C:9]1[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=1[O:7][CH2:6][CH2:5][C:4]([CH3:17])([CH3:16])[C:3](=[O:18])[CH2:2][N:25]1[CH:29]=[N:28][CH:27]=[N:26]1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 132414241-Chloro-5-(2,4-dichlorophenoxy)-3,3-dimethylpentan-2-one

Product 1

HCID 13259981HCID 13259981, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

30.9 g (0.1 mol) of 1-chloro-5-(2,4-dichlorophenoxy)-3,3-dimethyl-2-pentanone, dissolved in 80 ml of acetone, are added dropwise, with stirring, to a mixture of 13.8 g (0.1 mol) of potassium carbonate and 13.8 g (0.2 mol) of 1,2,4-triazole in 200 ml of boiling acetone. The mixture is boiled for a further 3 hours, cooled down to 0° to 10° C., the salt is filtered off and the filtrate is evaporated in vacuo. After trituration of the oily residue with a little petroleum ether, 32.4 g (94.6% of theory) of 5-(2,4-dichlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-pentanone are obtained as colorless crystals of melting point 62° C.

Workup

  1. additionare added dropwise
  2. temperaturecooled down to 0° to 10° C.
  3. filtrationthe salt is filtered off
  4. customthe filtrate is evaporated in vacuo

Sources & evidence

ORD record
ord-72fe7761cf55472a8222db23d2a6916a
Source dataset
uspto-grants-1988_03
Patent number
US04731452

Reaction notes

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