Ethylamine → HCID 13361995, compound

HRID 569248Notes

Reaction equation

HRID 569248 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=[O:14])[O:11][C:9]2=[O:10])=[CH:4][CH:3]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH:20]=O.[CH2:25]([NH2:27])[CH3:26]>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:9]([OH:11])=[O:10])[CH:20]([C:19]3[CH:22]=[CH:23][CH:24]=[C:17]([O:16][CH3:15])[CH:18]=3)[N:27]([CH2:25][CH3:26])[C:12](=[O:14])[CH2:13]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6341EthylamineHCID 115693-MethoxybenzaldehydeHCID 2894693-(4-chlorophenyl)dihydrofuran-2,5-dione

Product 1

HCID 13361995HCID 13361995, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
0 °C

Procedure

8.13 g of (4-chlorophenyl)-succinic anhydride (0.0386 mole) and 6.3 g (0.0386 mole) of Schiff base, prepared from 3-methoxybenzaldehyde and ethylamine, are refluxed in 100 ml of xylene at 140° C. for 12 hr. After cooling to 0° C. the solid is collected and washed with xylene and ether: 11.5 g (84%) of title compound mp 153°-6° C. (diastereoisomeric mixture).

Workup

  1. customis collected
  2. washwashed with xylene and ether

Sources & evidence

ORD record
ord-95033e68c20c4cae83b9d2eec7672026
Source dataset
uspto-grants-1988_03
Patent number
US04731457

Reaction notes

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