Sodium Bicarbonate → Sodium 1-[2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]cyclobutane-1-carboxylate

HRID 569268Notes

Reaction equation

HRID 569268 reaction equation
[Cl:1][C:2]1[C:15]([Cl:16])=[C:14]([C:17](=[O:22])[C:18](=[CH2:21])[CH2:19][CH3:20])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1([C:9]([OH:11])=[O:10])[CH2:8][CH2:7][CH2:6]1.C(=O)(O)[O-].[Na+:27]>O>[Cl:1][C:2]1[C:15]([Cl:16])=[C:14]([C:17](=[O:22])[C:18](=[CH2:21])[CH2:19][CH3:20])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1([C:9]([O-:11])=[O:10])[CH2:8][CH2:7][CH2:6]1.[Na+:27]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 139587401-[2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]cyclobutane-1-carboxylic acid

Product 1

HCID 23718748Sodium 1-[2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]cyclobutane-1-carboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.103 g of 1-[2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]cyclobutane-1-carboxylic acid is dissolved 33 ml of 0.1N sodium bicarbonate and with isotonic saline to make a final volume of 100 ml. The water from all sources was pyrogen free. The solution is sterilized by filtration. This solution is 3 mM in active antisickling agent.

Workup

  1. filtrationThe solution is sterilized by filtration

Sources & evidence

ORD record
ord-651da5f47d90443e9974de384ccf527a
Source dataset
uspto-grants-1988_03
Patent number
US04731473

Reaction notes

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