Hydrochloric Acid → HCID 14099853, compound

Participants

Reaction Steps

[6,7-Dichloro-2,3-dihydro-1-oxo-2-(3-oxo-butyl)-2-propyl-1H-inden-5-yl]acetic acid (3.0 g, 0.00808 mole) was dissolved in 25 ml 1N sodium hydroxide and 6 ml water, stirred at room temperature for 70 hours and then the reaction was diluted with water and acidified with hydrochloric acid. The product was extracted with methylene chloride, the organic extracts were washed with water, dried over MgSO4, concentrated under vacuum and the residue recrystallized from acetonitrile to obtain the product, mp 206°-8°C.

Provenance & Evidence