Hydrochloric Acid → HCID 14099853, compound

HRID 569279Notes

Reaction equation

HRID 569279 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH2:16][CH2:17][C:18](=[O:20])[CH3:19])([CH2:13][CH2:14][CH3:15])[C:8]2=O)=[CH:4][C:3]=1[CH2:21][C:22]([OH:24])=[O:23].Cl>[OH-].[Na+].O>[Cl:11][C:10]1[C:2]([Cl:1])=[C:3]([CH2:21][C:22]([OH:24])=[O:23])[CH:4]=[C:5]2[C:9]=1[C:8]1[C:7]([CH2:13][CH2:14][CH3:15])([CH2:6]2)[CH2:16][CH2:17][C:18](=[O:20])[CH:19]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 14099852HCID 14099852, compound

Product 1

HCID 14099853HCID 14099853, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 14798Sodium HydroxideSolvent

Procedure

[6,7-Dichloro-2,3-dihydro-1-oxo-2-(3-oxo-butyl)-2-propyl-1H-inden-5-yl]acetic acid (3.0 g, 0.00808 mole) was dissolved in 25 ml 1N sodium hydroxide and 6 ml water, stirred at room temperature for 70 hours and then the reaction was diluted with water and acidified with hydrochloric acid. The product was extracted with methylene chloride, the organic extracts were washed with water, dried over MgSO4, concentrated under vacuum and the residue recrystallized from acetonitrile to obtain the product, mp 206°-8°C.

Workup

  1. extractionThe product was extracted with methylene chloride
  2. washthe organic extracts were washed with water
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated under vacuum
  5. customthe residue recrystallized from acetonitrile
  6. customto obtain the product, mp 206°-8°C.

Sources & evidence

ORD record
ord-e3b2872311a9482fa87a3ce10b5608ea
Source dataset
uspto-grants-1988_03
Patent number
US04731472

Reaction notes

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