反应详情

3-[6,7-Dichloro-2,3-dihydro-1-oxo-2-(3-oxobutyl)-2-propyl-inden-5-yl]propionic acid (3.1 g, 0.00805 mole) was stirred at 25° C. in a mixture of methanol (2 ml), water (6 ml) and 1N sodium hydroxide (25 ml) for 96 hours. After dilution with water, the mixture was acidified with hydrochloric acid and extracted with a mixture of diethyl ether and tetrahydrofuran. The organic extracts were washed with water, dried over MgSO4 and concentrated under vacuum. The residue was recrystallized from acetic acid-acetonitrile (1:1) to obtain the product mp 201°-3° C.

1. extractionextracted with a mixture of diethyl ether and tetrahydrofuran
2. washThe organic extracts were washed with water
3. dry with materialdried over MgSO4
4. concentrationconcentrated under vacuum
5. customThe residue was recrystallized from acetic acid-acetonitrile (1:1)