Sodium Bicarbonate → HCID 86742045, compound

HRID 569310Notes

Reaction equation

HRID 569310 reaction equation
[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([O:16][CH2:17][C:18]([OH:20])=[O:19])[CH:12]=[C:11]2[C:3]=1[C:4]1[C:9]([CH2:21][CH2:22][OH:23])([CH2:10]2)[CH2:8][CH2:7][C:6](=[O:24])[CH:5]=1.C(=O)(O)[O-].[Na+:29]>O>[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([O:16][CH2:17][C:18]([O-:20])=[O:19])[CH:12]=[C:11]2[C:3]=1[C:4]1[C:9]([CH2:21][CH2:22][OH:23])([CH2:10]2)[CH2:8][CH2:7][C:6](=[O:24])[CH:5]=1.[Na+:29]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 14098158HCID 14098158, compound

Product 1

HCID 86742045HCID 86742045, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

{[5,6-Dichloro-9a-(2-hydroxyethyl)-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl]oxy}acetic acid (500 mg) is dissolved by stirring and warming with 0.25N sodium bicarbonate solution (5.4 ml). The solution is diluted to 10 ml and sterilized by filtration. All the water that is used in the preparation is pyrogen-free. The concentration of the active agent in the final solution is 5%.

Workup

  1. additionThe solution is diluted to 10 ml and sterilized by filtration

Sources & evidence

ORD record
ord-e813937397074153838a63117de2849b
Source dataset
uspto-grants-1988_03
Patent number
US04731471

Reaction notes

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