Trifluoroacetic acid → HCID 117622677, compound

HRID 56944Notes

Reaction equation

[Cl:1][C:2]1[C:3]([C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=2[C:31]#[N:32])=[CH:4][C:5](=[O:23])[N:6]([CH:8]([CH2:16][C@@H:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)[C:9]([O:11]C(C)(C)C)=[O:10])[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[C:3]([C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=2[C:31]#[N:32])=[CH:4][C:5](=[O:23])[N:6]([CH:8]([CH2:16][C@@H:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)[C:9]([OH:11])=[O:10])[CH:7]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 117622734tert-Butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-[(2S)-tetrahydro-2H-pyran-2-yl]propanoate

Product 1

HCID 117622677HCID 117622677, compound

Procedure

396 mg (0.83 mmol) of tert-butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-[(2S)-tetrahydro-2H-pyran-2-yl]propanoate (mixture of enantiomerically pure diastereomers 1 and 2) were hydrolysed with TFA according to General Method 6A. Yield: 396 mg (quant.)

Sources & evidence

ORD record: ord-6d58c61c5f424a9585abce61b0d4509d
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09434690B2

Reaction notes

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