Trifluoroacetic acid → HCID 117622818, compound

HRID 56946Notes

Reaction equation

HRID 56946 reaction equation
[Cl:1][C:2]1[C:3]([C:21]2[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:4][C:5](=[O:20])[N:6]([CH:8]([CH2:16][CH2:17][O:18][CH3:19])[C:9]([O:11]C(C)(C)C)=[O:10])[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[C:3]([C:21]2[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=2[C:28]#[N:29])=[CH:4][C:5](=[O:20])[N:6]([CH:8]([CH2:16][CH2:17][O:18][CH3:19])[C:9]([OH:11])=[O:10])[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622727tert-Butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-4-methoxybutanoate

Product 1

HCID 117622818HCID 117622818, compound

Procedure

455 mg (purity 80%, 0.83 mmol) of tert-butyl 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-4-methoxybutanoate (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 417 mg (purity 76%, quant.)

Sources & evidence

ORD record
ord-e706359340ac4a21bdf2f757814094f8
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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