Acetonitrile → 1-[5-Methyl-2-(3-methyl-4-pyridinyl)-1H-imidazol-4-yl]ethanone

Participants

Reaction Conditions

Reaction Steps

A mixture of 7.1 g of 3-methyl-4-pyridylmethylamine, 6.25 g of 2,3,4-pentanetrione, 3-oxime and 125 ml of acetonitrile was stirred at reflux temperature for 5 hours, then cooled at -10° C. The resulting precipitate was collected, washed with cold acetonitrile, dried and then recrystallized from a mixture of chloroform and hexane, giving 4.5 g of the desired compound, mp 185°-187° C.

Provenance & Evidence