Bromine → HCID 131715475, compound

HRID 569464Notes

Reaction equation

HRID 569464 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[C:13](=[O:15])[CH3:14].[Br:16]Br>Br>[BrH:16].[BrH:16].[Br:16][CH2:14][C:13]([C:3]1[N:4]=[C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[NH:6][C:2]=1[CH3:1])=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 13387922HCID 13387922, compound

Product 1

HCID 131715475HCID 131715475, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
80 °C

Procedure

To a stirred solution of 10 g of 1-[5-methyl-2-(3-pyridinyl)-1H-imidazol-4-yl]ethanone in 60 ml of 48% hydrobromic acid at 80° C. was added, dropwise during 5-10 minutes, 2.8 ml of bromine. After addition was complete, the mixture was stirred at 80° C. for 10 minutes, then allowed to cool to room temperature. The resulting solid was collected, washed with three 25 ml portions of acetone and dried, giving 13.4 g of 2-bromo-1-[5-methyl-2-(3-pyridinyl)-1H-imidazol-4-yl]ethanone, dihydrobromide.

Workup

  1. additionAfter addition
  2. temperatureto cool to room temperature
  3. customThe resulting solid was collected
  4. washwashed with three 25 ml portions of acetone
  5. customdried

Sources & evidence

ORD record
ord-ddc3f8b5f30f4371b57b8ea268f4a208
Source dataset
uspto-grants-1988_03
Patent number
US04732895

Reaction notes

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