2-Pyrazinecarboxylic acid → Pyrazinecarbonyl chloride
Reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.C(Cl)[Cl:11].S(Cl)(Cl)=O>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([Cl:11])=[O:9]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
A mixture of 68.2 g (0.55 moles) 2-pyrazine carboxylic acid and methylene chloride (about 200 ml) containing a catalytic amount of pyridine was warmed (to about 30° C.). To that mixture, 78.5 g (0.66 mole) thionyl chloride was added dropwise. The reaction mixture was refluxed for 24 hours. The methylene chloride was removed under reduced pressure and heat to give the 2-pyrazine carboxylic acid chloride which was used in step (b) without further isolation.
Workup
- temperatureThe reaction mixture was refluxed for 24 hours
- customThe methylene chloride was removed under reduced pressure
- temperatureheat
Sources & evidence
- ORD record
- ord-eeecef3d2dfe44ea81cf3a66696f3e90
- Source dataset
- uspto-grants-1988_03
- Patent number
- US04732894
Reaction notes
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