反应详情

A mixture of 2,4-octanedione (7.11 g, 0.50 mole) and dimethylformamide dimethylacetal (7.15 g, 0.60 mole) was stirred overnight at room temperature overnight under argon. The resulting red liquid was concentrated on the rotary evaporation then distilled on the kugelrohr at -15 mm, 140°-155° C. to yield 8.60 g (87%) of 3-[(dimethylamino)methyleno]-2,4-octanodione.

1. concentrationThe resulting red liquid was concentrated on the rotary evaporation
2. distillationthen distilled on the kugelrohr at -15 mm, 140°-155° C.
3. customto yield 8.60 g (87%) of 3-[(dimethylamino)methyleno]-2,4-octanodione