Trifluoroacetic acid → HCID 86297341, compound

HRID 56958Notes

Reaction equation

HRID 56958 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]([CH:15]([CH3:32])[C:16]([NH:18][C:19]2[CH:31]=[CH:30][C:22]([C:23]([O:25]C(C)(C)C)=[O:24])=[CH:21][CH:20]=2)=[O:17])[C:11](=[O:33])[CH:10]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]([CH:15]([CH3:32])[C:16]([NH:18][C:19]2[CH:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:30][CH:31]=2)=[O:17])[C:11](=[O:33])[CH:10]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622667Tert-butyl 4-(2-(4-(2,5-dichlorophenyl)-2-oxopyridin-1(2h)-yl)propanamido)benzoate

Product 1

HCID 86297341HCID 86297341, compound

Procedure

83 mg (0.17 mmol) of tert-butyl 4-({2-[4-(2,5-dichlorophenyl)-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoate (racemate) (Example 2.9C) were hydrolysed with TFA according to General Method 2. Yield: 21 mg (purity 88%, 23% of theory)

Sources & evidence

ORD record
ord-26c7a928db004209a8ddb90df44fe62b
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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