2,2,2-Trifluoroethanol → Diethyl Aluminum 2,2,2-Trifluoroethoxide

Participants

Reaction Steps

Under a nitrogen atmosphere, 81.36 g (0.71 mole) of triethylaluminum was placed in a flask immersed in a chilled oil bath (-20° C.). In an addition funnel there was placed 77 g (0.77 mole) of 2,2,2-trifluoroethanol. Temperature of the reaction mixture was permitted to rise to 10° C., at which point addition of the trifluoroethanol commenced. The temperature was slowly raised by increasing the speed of addition and at the end of the addition of the alcohol was 40° C. The total time consumed was one hour.

Provenance & Evidence