2,2,2-Trifluoroethanol → Diethyl Aluminum 2,2,2-Trifluoroethoxide

HRID 569599Notes

Reaction equation

HRID 569599 reaction equation
[CH2:1]([Al:3](CC)[CH2:4][CH3:5])[CH3:2].[F:8][C:9]([F:13])([F:12])[CH2:10][OH:11]>>[F:8][C:9]([F:13])([F:12])[CH2:10][O-:11].[CH2:1]([Al+:3][CH2:4][CH3:5])[CH3:2]

Participants

3

Reactant 2

HCID 64092,2,2-Trifluoroethanol2×HCID 16682930Triethylaluminum

Product 1

HCID 21290503Diethyl Aluminum 2,2,2-Trifluoroethoxide

Procedure

Under a nitrogen atmosphere, 81.36 g (0.71 mole) of triethylaluminum was placed in a flask immersed in a chilled oil bath (-20° C.). In an addition funnel there was placed 77 g (0.77 mole) of 2,2,2-trifluoroethanol. Temperature of the reaction mixture was permitted to rise to 10° C., at which point addition of the trifluoroethanol commenced. The temperature was slowly raised by increasing the speed of addition and at the end of the addition of the alcohol was 40° C. The total time consumed was one hour.

Workup

  1. customimmersed in a chilled oil bath
  2. custom(-20° C.)
  3. customIn an addition funnel there was placed
  4. temperatureThe temperature was slowly raised
  5. temperatureby increasing
  6. additionthe speed of addition
  7. customwas 40° C
  8. customThe total time consumed

Sources & evidence

ORD record
ord-7a3bf384b47048e4a33ad1912a8cc6b4
Source dataset
uspto-grants-1988_03
Patent number
US04732993

Reaction notes

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