2,2,2-Trifluoroethanol → Ethylaluminum Di-(2,2,2-trifluoroethoxide)
Reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3][O-:4].[CH2:7]([Al+:9]CC)[CH3:8].[F:12][C:13]([F:17])([F:16])[CH2:14][OH:15].[Al]>>[F:1][C:2]([F:6])([F:5])[CH2:3][O-:4].[F:12][C:13]([F:17])([F:16])[CH2:14][O-:15].[CH2:7]([Al+2:9])[CH3:8]Participants
4
Conditions
- Temperature
- 55 °C
Procedure
In a flask were placed 10.27 g (55.75 mmoles) of the product of Example 1, under a nitrogen blanket. Then, 5.71 g (0.058 mole) of 2,2,2-trifluoroethanol was added dropwise. When the reaction mixture temperature reached 50° C., the flask was immersed in a chilled oil bath (0° C.) and the addition of fluoroalkanol was continued at a rate sufficient to maintain the temperature at 50°-55° C. After addition was completed, the reaction mixture was stirred for one hour at 55° C. The product was a viscous, colorless liquid. Analysis for aluminum showed 10.43% Al, which correlated well with the theoretical value of 10.58%.
Workup
- customIn a flask were placed
- customreached 50° C.
- customthe flask was immersed in a chilled oil bath
- temperatureto maintain the temperature at 50°-55° C
- additionAfter addition
Sources & evidence
- ORD record
- ord-57b6c6e955ac4a9e96b0f3294f848f1d
- Source dataset
- uspto-grants-1988_03
- Patent number
- US04732993
Reaction notes
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