Formic Acid → 3-(Phthalimido)-propyl formate

HRID 569610Notes

Reaction equation

HRID 569610 reaction equation
[C:1]1(=[O:15])[N:5]([CH2:6][CH2:7][CH2:8][OH:9])[C:4](=[O:10])[C:3]2=[CH:11][CH:12]=[CH:13][CH:14]=[C:2]12.[CH:16](O)=[O:17]>>[CH:16]([O:9][CH2:8][CH2:7][CH2:6][N:5]1[C:4](=[O:10])[C:3]2=[CH:11][CH:12]=[CH:13][CH:14]=[C:2]2[C:1]1=[O:15])=[O:17]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 701602-(3-Hydroxypropyl)isoindoline-1,3-dione

Product 1

HCID 201478623-(Phthalimido)-propyl formate

Procedure

A mixture of 3-(phthalimido)-propanol (20.5 g) and formic acid (33 ml) was refluxed overnight and evaporated in vacuo to leave a yellow oil which crystallized from absolute ethanol to give colourless crystals with m.p. 68°-70° C.

Workup

  1. temperaturewas refluxed overnight
  2. customevaporated in vacuo
  3. customto leave a yellow oil which
  4. customcrystallized from absolute ethanol
  5. customto give colourless crystals with m.p. 68°-70° C.

Sources & evidence

ORD record
ord-106fdf697b954067947f319948b90715
Source dataset
uspto-grants-1988_03
Patent number
US04732998

Reaction notes

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