Hydrochloric Acid → HCID 20147880, compound

HRID 569613Notes

Reaction equation

HRID 569613 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][O:9][CH:10]([P:19](=[O:26])([O:23]CC)[O:20]CC)[P:11](=[O:18])([O:15]CC)[O:12]CC)C(=O)C2=CC=CC=C12.Cl>O>[NH2:5][CH2:6][CH2:7][CH2:8][O:9][CH:10]([P:19](=[O:20])([OH:23])[OH:26])[P:11](=[O:12])([OH:15])[OH:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54233076HCID 54233076, compound

Product 1

HCID 20147880HCID 20147880, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of tetraethyl (3-(phthalimido)-propoxymethylene)-bisphosphonate (4.4 g) and 6N hydrochloric acid (25 ml) was refluxed overnight. After cooling, the mixture was diluted with water and extracted twice with ether. The aqueous phase was evaporated to dryness, and the residue was stirred with absolute ethanol. The title compound was isolated by filtration and dried in vacuo.

Workup

  1. temperaturewas refluxed overnight
  2. temperatureAfter cooling
  3. extractionextracted twice with ether
  4. customThe aqueous phase was evaporated to dryness

Sources & evidence

ORD record
ord-1451303e84f8455a83e74907eb91de33
Source dataset
uspto-grants-1988_03
Patent number
US04732998

Reaction notes

Loading…