Tetraethyl (1-phenoxypropylidene)-bisphosphonate → (1-Phenoxypropylidene)-bisphosphonic acid

HRID 569618Notes

Reaction equation

HRID 569618 reaction equation
[O:1]([C:8]([P:19](=[O:26])([O:23]CC)[O:20]CC)([P:11](=[O:18])([O:15]CC)[O:12]CC)[CH2:9][CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C[Si](C)(C)Br>[O:1]([C:8]([P:19](=[O:20])([OH:23])[OH:26])([P:11](=[O:12])([OH:15])[OH:18])[CH2:9][CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 53742288Tetraethyl (1-phenoxypropylidene)-bisphosphonate

Product 1

HCID 20147886(1-Phenoxypropylidene)-bisphosphonic acid

Reagents, catalysts & solvents 1

HCID 76113BromotrimethylsilaneSolvent

Procedure

A solution of tetraethyl (1-phenoxypropylidene)-bisphosphonate (2.1 g) in trimethyl bromosilane (8 ml) was kept at room temperature overnight, followed by evaporation in vacuo. The residue was stirred overnight in absolute ethanol. Evaporation in vacuo gave the desired compound.

Workup

  1. customfollowed by evaporation in vacuo
  2. customEvaporation in vacuo

Sources & evidence

ORD record
ord-ce4bfa27ba54486e83aac61cf44faeef
Source dataset
uspto-grants-1988_03
Patent number
US04732998

Reaction notes

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