Acetic Acid → HCID 178429187, compound

HRID 569699Notes

Reaction equation

HRID 569699 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][S:10]([C:13]1[N:17]=[C:16]([NH2:18])[NH:15][N:14]=1)(=[O:12])=[O:11].C(O)(=O)C.[C:23](OCC)(=[O:28])[CH2:24][C:25]([CH3:27])=O>CO>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[NH:9][S:10]([C:13]1[N:17]=[C:16]2[N:18]=[C:25]([CH3:27])[CH:24]=[C:23]([OH:28])[N:15]2[N:14]=1)(=[O:12])=[O:11]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 8868Ethyl AcetoacetateHCID 178509071HCID 178509071, compound

Product 1

HCID 178429187HCID 178429187, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5.0 g (14.3 mmol) of N-(2,6-dichlorophenyl)-5-amino-1,2,4-triazol-3-sulfonamide, 0.5 ml of acetic acid, and 2.0 ml (15.6 mmol) of ethyl acetoacetate in 100 ml of absolute methanol was heated at reflux for 48 hr. After 24 hr a solid began to form. The solution was cooled and the solid collected. After drying, 4.0 g (75 percent) of the desired product was obtained as a white powder; mp 302° C. decomposes.

Workup

  1. temperatureat reflux for 48 hr
  2. customto form
  3. temperatureThe solution was cooled
  4. customthe solid collected
  5. customAfter drying

Sources & evidence

ORD record
ord-97474c08dac84f76a6d8a098ab21cb19
Source dataset
uspto-grants-1988_03
Patent number
US04734123

Reaction notes

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