Hydrochloric Acid → HCID 14152234, compound

HRID 569702Notes

Reaction equation

HRID 569702 reaction equation
[CH3:1][O-:2].[Na+].[CH3:4][OH:5].[Cl:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:8]=1[NH:14][S:15]([C:18]1[N:28]=[C:21]2[N:22]=[C:23](Cl)[CH:24]=[C:25](Cl)[N:20]2[N:19]=1)(=[O:17])=[O:16].Cl>>[Cl:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:8]=1[NH:14][S:15]([C:18]1[N:28]=[C:21]2[N:22]=[C:23]([O:5][CH3:4])[CH:24]=[C:25]([O:2][CH3:1])[N:20]2[N:19]=1)(=[O:17])=[O:16]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14152233HCID 14152233, compoundHCID 23694274Sodium methanolate methanol

Product 1

HCID 14152234HCID 14152234, compoundYield 41.2%

Procedure

A solution of 20 ml (9.6 mmol) of sodium methoxide-methanol was treated with 1.0 g (2.4 mmol) of N-(2,6-dichlorophenyl)-5,7-dichloro-1,2,4-triazolo-[1,5-a]pyrimidine-2-sulfonamide and was stirred for 15 minutes at 25°-30° C. The solution was acidified with 6N aqueous HCl and then concentrated by rotary evaporation in vacuo. The residue was washed with water and then triturated with warm isopropanol (2X) to afford 0.4 g (41 percent) of a white powder; mp 232°-234° C. decomposition.

Workup

  1. concentrationconcentrated by rotary evaporation in vacuo
  2. washThe residue was washed with water
  3. customtriturated with warm isopropanol (2X)

Sources & evidence

ORD record
ord-f156f6ca008541ca970dcf8066f0632d
Source dataset
uspto-grants-1988_03
Patent number
US04734123

Reaction notes

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