反应详情

Into a Parr bottle containing 5.0 grams (24.8 mmol) of 2,5-dimethyl-6-chloro-4-nitrophenol in 40 milliliters of ethyl alcohol was added 0.5 grams of 5 percent platinum on carbon. This mixture was hydrogenated for 45 minutes in a Parr apparatus. The resulting solution was filtered over charcoal and Celite and the solvent was evaporated to afford 4.09 grams of 2,5-dimethyl-6-chloro-4-aminophenol having a melting point of 127° C.-128° C. Recrystallization from ethyl acetate and hexane afforded a product having a melting point of 129° C.-130° C. Elemental analysis of the product indicated the following:

1. filtrationThe resulting solution was filtered over charcoal and Celite
2. customthe solvent was evaporated