Thionyl Chloride → HCID 19921765, compound

HRID 569734Notes

Reaction equation

HRID 569734 reaction equation
[ClH:1].[CH2:2]1[C:9]2([C:10]([OH:12])=O)[N:5]([CH2:6][CH2:7][CH2:8]2)[CH2:4][CH2:3]1.S(Cl)([Cl:15])=O>>[ClH:15].[CH2:2]1[C:9]2([C:10]([Cl:1])=[O:12])[N:5]([CH2:6][CH2:7][CH2:8]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 44118652Tetrahydro-1H-pyrrolizine-7a(5H)-carboxylic acid hydrochloride

Product 1

HCID 19921765HCID 19921765, compoundYield 95.9%

Procedure

A mixture of pyrrolizidine-7a-carboxylic acid hydrochloride (24.6 g, 0.128 mol, prepared as described in Reference Example 2) and thionylchloride (280 ml, 3.89 mol) was stirred for 17 hours at 20° to 25° C. and the excess of thionylchloride was evaporated in vacuo to give 25.7g (95.9%) of the desired compound, as yellowish solids.

Workup

  1. customthe excess of thionylchloride was evaporated in vacuo

Sources & evidence

ORD record
ord-a8a6f945fcd14f9cbd87cd56c84cc2ed
Source dataset
uspto-grants-1988_03
Patent number
US04734411

Reaction notes

Loading…