Trifluoroacetic acid → HCID 117622752, compound

HRID 56974Notes

Reaction equation

HRID 56974 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:39]([F:42])([F:41])[F:40])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:31][C:32]3[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=3)[C:15]([NH:17][C:18]3[CH:30]=[CH:29][C:21]([C:22]([O:24]C(C)(C)C)=[O:23])=[CH:20][CH:19]=3)=[O:16])[C:10](=[O:38])[CH:9]=2)[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:39]([F:42])([F:40])[F:41])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:31][C:32]3[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=3)[C:15]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([C:22]([OH:24])=[O:23])=[CH:29][CH:30]=3)=[O:16])[C:10](=[O:38])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622867tert-Butyl 4-{[2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-(pyridin-4-yl)propanoyl]amino}benzoate

Product 1

HCID 117622752HCID 117622752, compound

Procedure

383 mg (0.62 mmol) of tert-butyl 4-{[2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-(pyridin-4-yl)propanoyl]amino}benzoate (racemate) (Example 10.1C) were hydrolysed with TFA according to General Method 2. Yield: 180 mg (53% of theory)

Sources & evidence

ORD record
ord-8e020b4d789040f6a98ca793dad0e738
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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