Methanol → 5-(2,1-Benzisothiazol-6-yl)-2,4-imidazolidinedione

HRID 569747Notes

Reaction equation

HRID 569747 reaction equation
[N:1]1[S:2][CH:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][C:5]=12.[CH3:12][OH:13].[C-]#N.[Na+].[C:17](=[O:20])([O-])[O-].[NH4+:21].[NH4+:22]>C(O)C.O>[N:1]1[S:2][CH:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH:10]3[NH:22][C:12](=[O:13])[NH:21][C:17]3=[O:20])=[CH:6][C:5]=12

Participants

7

Reactant 4

HCID 887MethanolHCID 8929Sodium CyanideHCID 517111Ammonium CarbonateHCID 201462602,1-Benzisothiazole-6-carboxaldehyde

Product 1

HCID 201462615-(2,1-Benzisothiazol-6-yl)-2,4-imidazolidinedione

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

18.6 g (0.114 mole) of 10c are stirred analogously to Example 1c in ethanol, methanol and water with 8.4 g (0.171 mole) of sodium cyanide and 43.8 g (0.456 mole) of ammonium carbonate at 60° C. for 16 hours.

Sources & evidence

ORD record
ord-23669f41ba574c43847900f1d46071d8
Source dataset
uspto-grants-1988_03
Patent number
US04734407

Reaction notes

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