HCID 22837354, compound → HCID 22837353, compound

HRID 569758Notes

Reaction equation

HRID 569758 reaction equation
[N:1]([C@H:4]1[CH2:10][CH2:9][C@@H:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7][N:6]([CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:5]1=[O:25])=[N+]=[N-]>[Pd]>[NH2:1][C@H:4]1[CH2:10][CH2:9][C@@H:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7][N:6]([CH2:17][C:18]([O:20][C:21]([CH3:23])([CH3:22])[CH3:24])=[O:19])[C:5]1=[O:25]

Participants

3

Reactant 1

HCID 22837354HCID 22837354, compound

Product 1

HCID 22837353HCID 22837353, compoundYield 102.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Reduction of 1.9 g of t-butyl α-[3(S*)-azido-2-oxo-6(S*)-phenylperhydroazepin-1-yl]acetate (Isomer B) [prepared as described in Example 1(i)] with 5% w/w palladium-on-carbon in a similar manner to that described in Example 1(j) gave 1.8 g of the title compound as a gummy substance.

Sources & evidence

ORD record
ord-3fc2160b7ca34e649435599b767b2f34
Source dataset
uspto-grants-1988_03
Patent number
US04734410

Reaction notes

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