HCID 22837343, compound → HCID 22837345, compound

HRID 569760Notes

Reaction equation

[NH2:1][C@@H:2]1[CH2:8][CH2:7][C@@H:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH2:5][N:4]([CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:3]1=[O:24].[C:25]1([CH2:31][CH2:32][C@@H:33](OS(C(F)(F)F)(=O)=O)[C:34]([O:36][CH2:37][CH2:38][CH2:39][CH3:40])=[O:35])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:37]([O:36][C:34]([C@@H:33]([NH:1][CH:2]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH2:5][N:4]([CH2:16][C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])[C:3]1=[O:24])[CH2:32][CH2:31][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:35])[CH2:38][CH2:39][CH3:40]

Participants

Reactant 2

HCID 22837343HCID 22837343, compound

HCID 86742066HCID 86742066, compound

Product 1

HCID 22837345HCID 22837345, compound

Procedure

According to a similar procedure to that described in Example 1(l), t-butyl α-[3(S*)-amino-6(R*)-(p-fluorophenyl)-2-oxoperhydroazepin-1-yl]acetate [prepared as described in Example 6(e)] was reacted with butyl 4-phenyl-2(R)-trifluoromethanesulfonyloxybutyrate, to give a crude product, which was subjected to column chromatography through silica gel using a 3:1 by volume mixture of cyclohexane and ethyl acetate as eluent.

Sources & evidence

ORD record: ord-fd64dfa5e9904d1bacc74f2b0a025850
Source dataset: uspto-grants-1988_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04734410

Reaction notes

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