HCID 14099442, compound → HCID 14099441, compound

HRID 569784Notes

Reaction equation

HRID 569784 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH2:15][CH2:16][C:17](=[O:20])[NH:18][N:19]=3)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[OH:21][CH:22]1CCCN(C2C=CC(C3CCC(=O)NN=3)=CC=2)[CH2:23]1>>[O:21]1[C:2]2([CH2:7][CH2:6][N:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]4[CH2:15][CH2:16][C:17](=[O:20])[NH:18][N:19]=4)=[CH:10][CH:9]=3)[CH2:4][CH2:3]2)[O:1][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 14099442HCID 14099442, compoundHCID 14099443HCID 14099443, compound

Product 1

HCID 14099441HCID 14099441, compound

Procedure

Following the procedure described in Example 38 but using a molar equivalent quantity of the appropriate 3- and 4-hydroxypiperidine in place of 1,4-dioxa-8-azaspiro[4,5]decane one obtains the suitably substituted γ-oxobenzenebutanoic acids which upon cyclization with hydrazine gives the following compounds: 37b. 4,5-dihydro-6-[4-(4-hydroxy-1-piperidinyl)phenyl]-3(2H)-pyridazinone, mp 262°-263° C. 37c. 4,5-Dihydro-6-[4-(3-hydroxy-1-piperdinyl)phenyl)-3(2H)-pyridazinone, mp 211°-212° C.

Workup

  1. customgives the following compounds

Sources & evidence

ORD record
ord-43332e2d23bf4a16bd2214445e78f2d5
Source dataset
uspto-grants-1988_03
Patent number
US04734415

Reaction notes

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