HCID 14099442, compound → HCID 14099441, compound

Participants

Reaction Steps

Following the procedure described in Example 38 but using a molar equivalent quantity of the appropriate 3- and 4-hydroxypiperidine in place of 1,4-dioxa-8-azaspiro[4,5]decane one obtains the suitably substituted γ-oxobenzenebutanoic acids which upon cyclization with hydrazine gives the following compounds: 37b. 4,5-dihydro-6-[4-(4-hydroxy-1-piperidinyl)phenyl]-3(2H)-pyridazinone, mp 262°-263° C. 37c. 4,5-Dihydro-6-[4-(3-hydroxy-1-piperdinyl)phenyl)-3(2H)-pyridazinone, mp 211°-212° C.

Provenance & Evidence