Methanethiol → HCID 14698107, compound

HRID 569787Notes

Reaction equation

HRID 569787 reaction equation
[CH3:1][SH:2].F[C:4]1[CH:18]=[CH:17][C:7]([C:8]([C:10]2[S:14][C:13](=[O:15])[NH:12][C:11]=2[CH3:16])=[O:9])=[CH:6][CH:5]=1>C(O)C>[CH3:16][C:11]1[NH:12][C:13](=[O:15])[S:14][C:10]=1[C:8](=[O:9])[C:7]1[CH:17]=[CH:18][C:4]([S:2][CH3:1])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 878MethanethiolHCID 141522585-(4-Fluorobenzoyl)-4-methyl-1,3-thiazol-2(3H)-one

Product 1

HCID 14698107HCID 14698107, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Gaseus methylmercaptan is added to a solution of 5-(4-fluorobenzoyl)-4-methyl-2(3H)-thiazolone (4.7 g) in ethanol (200 ml) to saturation. The mixture is heated at 120° C. in a sealed stainless steel container for 16 hours. After cooling to ambient temperature, the mixture is evaporated to dryness. The residue is recrystallized twice from ethanol to give the title compound.

Workup

  1. customthe mixture is evaporated to dryness
  2. customThe residue is recrystallized twice from ethanol

Sources & evidence

ORD record
ord-fbab24ef11c248bdad4a086061127c68
Source dataset
uspto-grants-1988_03
Patent number
US04734422

Reaction notes

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