2-[5-Chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid → HCID 178460013, compound

HRID 56981Notes

Reaction equation

HRID 56981 reaction equation
[Cl:1][C:2]1[C:3]([C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[C:21]#[N:22])=[CH:4][C:5](=[O:13])[N:6]([CH:8]([CH3:12])[C:9]([OH:11])=O)[CH:7]=1.[F:23][C:24]([F:38])([F:37])[C:25]1[N:29]=[C:28]([C:30]2[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][CH:31]=2)[NH:27][N:26]=1>>[Cl:1][C:2]1[C:3]([C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[C:21]#[N:22])=[CH:4][C:5](=[O:13])[N:6]([CH:8]([CH3:12])[C:9]([NH:34][C:33]2[CH:35]=[CH:36][C:30]([C:28]3[NH:27][N:26]=[C:25]([C:24]([F:38])([F:37])[F:23])[N:29]=3)=[CH:31][CH:32]=2)=[O:11])[CH:7]=1

Participants

3

Reactant 2

HCID 1176225492-[5-Chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acidHCID 178507445HCID 178507445, compound

Product 1

HCID 178460013HCID 178460013, compound

Procedure

126 mg (purity 66%, 0.25 mmol) of 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) (Example 12.1D) and 64 mg (0.27 mmol) of 4-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]aniline (Example 1.1C) were reacted according to General Method 1. Yield: 76 mg (57% of theory)

Sources & evidence

ORD record
ord-cb6e972d98da4960bec613ae6b35a17f
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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