Trifluoroacetic acid → HCID 117622732, compound

HRID 56984Notes

Reaction equation

HRID 56984 reaction equation
[Cl:1][C:2]1[C:3]([C:30]2[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=2[C:37]#[N:38])=[CH:4][C:5](=[O:29])[N:6]([CH:8]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[C:9]([NH:11][C:12]2[CH:24]=[CH:23][C:15]([C:16]([O:18]C(C)(C)C)=[O:17])=[CH:14][CH:13]=2)=[O:10])[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[C:3]([C:30]2[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=2[C:37]#[N:38])=[CH:4][C:5](=[O:29])[N:6]([CH:8]([CH2:25][CH:26]2[CH2:27][CH2:28]2)[C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:23][CH:24]=2)=[O:10])[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622832HCID 117622832, compound

Product 1

HCID 117622732HCID 117622732, compound

Procedure

192 mg (0.34 mmol) of tert-butyl 4-({2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-cyclopropylpropanoyl}amino)benzoate (racemate) (Example 13.1D) were hydrolysed with TFA according to General Method 2. Yield: 141 mg (82% of theory)

Sources & evidence

ORD record
ord-4c2ecde70eb94fc2ad8460b134aa0cde
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

Loading…