反应详情

Glycine (5 mmol) was reacted with 4-biphenylcarbonyl chloride (about 5 mmol) in the presence of 1N NaOH solution (10 ml), ether (21 ml) and THF (2 ml) using the procedure described in Example 5. Most of the product precipitated as a solid on acidification of the aqueous layer during the work up. This was found to be quite insoluble in CHCl3 and EtOAc. It was largely dissolved in CH3CN (~35 ml) and filtered to remove insoluble material. Crystalline acid (0.81 g, 63%) was deposited on cooling, m.p. 207°-218° C. decomp.

1. customMost of the product precipitated as a solid on acidification of the aqueous layer during the work up
2. dissolutionIt was largely dissolved in CH3CN (~35 ml)
3. filtrationfiltered
4. customto remove insoluble material
5. temperatureon cooling