Trifluoroacetic acid → HCID 117622622, compound

HRID 56989Notes

Reaction equation

HRID 56989 reaction equation
C([C:5]1[CH:13]=[C:12]([NH:14][C:15](=[O:37])[CH:16]([N:18]2[CH:23]=[C:22]([C:24]#[N:25])[C:21]([C:26]3[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:27]=3[CH:33]3[CH2:35][CH2:34]3)=[CH:20][C:19]2=[O:36])[CH3:17])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(C)(C)C.C(O)(C(F)(F)F)=O>>[Cl:32][C:30]1[CH:29]=[CH:28][C:27]([CH:33]2[CH2:35][CH2:34]2)=[C:26]([C:21]2[C:22]([C:24]#[N:25])=[CH:23][N:18]([CH:16]([CH3:17])[C:15]([NH:14][C:12]3[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:13]=3)=[O:37])[C:19](=[O:36])[CH:20]=2)[CH:31]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118877929HCID 118877929, compound

Product 1

HCID 117622622HCID 117622622, compound

Procedure

66 mg (0.13 mmol) of tert-butyl 4-({2-[4-(5-chloro-2-cyclopropylphenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoic acid (racemate) (Example 18.3A) were hydrolysed with TFA according to General Method 2. Yield: 39 mg (68% of theory)

Sources & evidence

ORD record
ord-9f4899af8c4b4835b201c86493f8bd90
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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