HRID56991

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C(=O)Nc1ccc(C(=O)OC(C)(C)C)cc1)n1cc(C(F)(F)F)c(-c2cc(Cl)ccc2C#N)cc1=O

HCID117622568

未命名化合物

PRODUCTS

生成物

结构：CC(C(=O)Nc1ccc(C(=O)O)cc1)n1cc(C(F)(F)F)c(-c2cc(Cl)ccc2C#N)cc1=O

HCID117622945

未命名化合物

PROCEDURE

实验过程

251 mg (purity 79%, 0.36 mmol) of tert-butyl 4-({2-[4-(5-chloro-2-cyanophenyl)-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl]propanoyl}amino)benzoate (racemate) (Example 20.1E) were hydrolysed with TFA according to General Method 2. Yield: 35 mg (20% of theory)