Hydrochloric Acid → HCID 12899415, compound

HRID 569945Notes

Reaction equation

HRID 569945 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C(=O)C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12899414HCID 12899414, compound

Product 1

HCID 12899415HCID 12899415, compoundYield 78.2%

Procedure

The thus-obtained 21 g of 8-bromo-5-acetyloxy-3,4-dihydrocarbostyril are dispersed in 150 ml of 8N-hydrochloric acid. The dispersion is heated under reflux conditions for 3 hours and then cooled. Insoluble matter thus formed is separated by filtration, washed with water and dried, and recrystallized from methanol-water to obtain 14 g of 8-bromo-5-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 212°-213° C.

Workup

  1. temperatureThe dispersion is heated under reflux conditions for 3 hours
  2. temperaturecooled
  3. customInsoluble matter thus formed
  4. customis separated by filtration
  5. washwashed with water
  6. customdried
  7. customrecrystallized from methanol-water

Sources & evidence

ORD record
ord-5b284d439d07405a8c9d94bf80207417
Source dataset
uspto-grants-1988_03
Patent number
US04734416

Reaction notes

Loading…