反应详情

The thus obtained 30 g of 6-chloro-7-methoxy-3,4-dihydrocarbostyril are dispersed in 300 ml of 47%-hydrobromic acid aqueous solution and heated for 4 hours under refluxing condition. After cooling of the reaction mixture, the insoluble matter is separated by filtration, washed with water and dried. Recrystallization from methanol-chloroform obtains 25 g of 6-chloro-7-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 264°-266° C.

1. temperatureheated for 4 hours
2. temperatureunder refluxing condition
3. temperatureAfter cooling of the reaction mixture
4. customthe insoluble matter is separated by filtration
5. washwashed with water
6. customdried
7. customRecrystallization from methanol-chloroform